Biologics Formulation

Develop robust biologics formulations faster with less material!
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Biologic drugs can be inherently prone to degradation and instability, making designing safe, stable, and effective formulations a challenge. To overcome these issues, developers perform screening and stability studies to identify suitable formulations; however, the number of formulations that can be screened for each project is often constrained by short timelines and a limited supply of material. The CM3 Biologics Formulation System is an end-to-end workflow for supporting high throughput buffer creation, buffer exchange, stressing, and analysis allowing for the rapid development of both protein formulations and vaccine formulations.

  • Versatile liquid handling for formulating and analytical sample prep
    Easily transfer aqueous and viscous liquids between both vials and 96-well plates
  • Automated processing and stressing
    Heat, cool, stir, and shake formulations
  • Low-bioburden environment
    Create a low-bioburden environment using a HEPA-filtered enclosure
  • Non-destructive visual inspection
    Automate the often labor intensive task of visible particle detection (>80 μm), turbidity, and color measurements. Archive all data, including images, for later viewing
  • High throughput pH and viscosity measurements
    Completely automate pH measurements in vials or 96-well plates and measure viscosity measurements with as little as100 μL of material
  • Integrated informatics
    Use Freeslate LEA (Lab Execution and Analysis) software to create experiment designs and aggregate composition, process, and analytical data in a central database for easy viewing and reporting

For more information, download the Biologics Formulation product sheet

“We selected Freeslate’s technology because the system was designed for biologics formulation, combining key capabilities that can be used across both early and late stage development projects allowing us to screen a broader range of conditions and reduce product consumption while accelerating our clients’ development timelines.”

Click here to view complete set of CM3 elements.

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