Solutions for Small Molecule Applications

We recognized the need for high throughput solutions in small molecule drug development a number of years ago and introduced our first solution in 2001.

Since then we have developed a number of tools and capabilities for addressing the needs of scientists at every stage of the drug development process.

Preformulation Workflows

Our Solubility workflow evaluates solubility as a function of excipients (PEGs, Tweens, solubilizers, glycerol, etc.), buffers (i.e., pH), and simulated gastrointestinal fluids, and as a function of various process solvents (aqueous and organic) and temperatures.

Our high throughput Polymorph and Salt Selection workflow allows you to much more deeply understand a number of parameters including screening of:

• Freeacid, freebase, salt or API versus solvent composition and crystallization method (slurry, evaporation, cooling, precipitation).
• Crystallization versus counterion, solvent, and crystallization method.
• Crystallization versus neutral organic guest, solvent and crystallization method.

Our Forced Degradation workflow allows for the analysis of potential degradation products from candidate drugs for analytical method development and early stability assessment.

Organic Transformation and Process Optimizations Workflows

Our Organic Transformation workflow allows you to explore a number of reaction conditions to optimize organic synthesis including the screening of cycloadditions, chiral salt resolutions, and metal scavengers.

Our Process Optimization workflow allows you to optimize a variety of chemistry reactions including:

• Screening organic solvents (neat and mixed systems).
• Trituration studies (chiral and achiral purifications).
• Cross-coupling (C-C, C-N, C-O, C-S) reactions (Buchwald-Hartwig Aminations, Suzuki-Miyaura, Negishi, Kumada, Heck, Ullmann).
• Enantioselective reductions (hydrogenation and transfer hydrogenation).
• Heterogeneous hydrogenation, carbonylation, and hydroformylation, among others.

Formulation Development

Our high throughput workflow for drug-excipient compatability studies allows you to screen a broader range of compatibility studies, giving you more confidence in the formulation you choose.

Our Liquid Formulation high throughput workflow allows you to screen a broader range of liquid formulations to give you a greater level of confidence in the formulation you choose.

Other Applications

The versatility of our automation systems is best demonstrated from the breadth of our offerings. Our systems can perform simple sample prep for analytical tests or perform complex sample preparation for more challenging analytical tests depending on your needs.

Small Molecule Managed Services

As part of our commitment to meeting the needs of researchers in drug discovery, we offer managed services for small molecule workflows. This has resulted in a "hardening" of our technologies, making them the best on the market for high throughput small molecule drug development applications. Furthermore, it allows our customers to manage their capacity in a way that no other company can offer.

You can bring workflows into your company to develop expertise and address urgent project needs. At the same time, you can outsource less pressing projects to Freeslate where your samples will be run on the same workflows you have adopted in your labs. For customers currently running LEA in the labs, the data generated through us is uploaded into a centralized database through our LEA software, allowing for access to the data by anyone in your organization. This provides tremendous flexibility in managing your capacity while generating excellent data that can accelerate your decision making process.

Freeslate offers you a real, demonstrable return on investment, either with existing workflows, which can be tailored for specific needs, and with managed services. (For more about our development services, go to Services.)

Click here to learn more about our solutions for Small Molecule Drug Development and how they can help you deliver step-change gains in your R&D.